Osteoarthritis

Aku terang dekat dalam blog nih sbnrnye bukannyer aper. Kadang2 bosan study stail lame. So aku amek inisiatif nak buat nota dalam blog plak. So bley gak senang ingat kan? Ala lagi pun ak kena supplement tak macm kengkawan aku yg lain. Sume dah lepas. Mau tak tekanan. Tekanan melampau smpai migrain aku kena. Dah seminggu lebih aku batuk still tak baik2 even mkan ubat batuk. Nak kena bagi codein baru baik agaknyer. Tapi tu sume Allah punyer keje. Harap2 ak dikurniakan kesihatan supya dapat jawab exam dengan baik nnt.

So back to our main topic today is about osteoarthritis.

Definition
The degenerative joint disease involving the degeneration of articular cartilage.

So wut is the idea behind dis? Degeneration articular cartilage. Due to wat? Lack of collagen synthesis. Collagen is important in formation of the articular cartilage. U must remember dat.

So the pathogenesis pn lebey kurang ader kaitan dengan lack of collagen synthesis la kan. Eh yer ker ape yg ak ckap nih? Hehehe mntak maapla kalo salah. Kena tgk buku balik nih. Adoiyai...
Eh betulla ape ak ckap kot. So lets continue.

Actually ade beberapa faktor yg boleh menyebabkan osteoarthritis nih. First genetic factor. Chromosome 2 ngan 11 ader masalah.

2. Ageing factor. Which causing hormonal changes leading to decrease synthesis type II collagen. Long term weight bearing and wear and tear cause damage to the joint.

3. Predisposing factor. What i mean ade penyakit awal yg lain yg menyebabkan pnyakit osteoarthritis.
Such as septic arthritis.

4. Mechanical effect like obesity, previous joint deformities cab also contribute the joint destruction.

So al these can decrease protective proteoglycan in cartilage and imbalance in collagen synthesis. Low collagen synthesis will weaken the collagen network of the cartilage.

Cytokine like TnF , IL-1 cause decrease in functional chondrocyte so damage cartilage is not repaired.

Macro aku cite kendian la yer. Penat nak menulis nih. Aku bukannyer suke menulis sangat tapi nak examnyer pasal terpaksa la buat stail camni. Sajer jer nak buang angin kat sini. Hehe

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